“We are not building protective immunity against Omicron”: New studies show that people with Omicron are not protected from reinfection

Infection with the Omicron mutant does not improve the immunity of the carrier and does not reduce the risk of reinfection. This shows a new study conducted in the United Kingdom. This statement applies to everyone, including those who have received all three doses of the vaccine. Studies show that people infected with Covid in the first wave of the pandemic also have no improvement in their immune response when eventually sacrificed by the Omicron mutant.

Study published on Tuesday Science, It helps explain why there are so many cases of reinfection with Omicron waves, such as those who have been infected twice with Omicron itself and those who are essential to the debate over herd immunity.

The idea that contracting a new variant may be a way to gain some immunity to the virus and prevent reinfection has been questioned by the discovery of new research. “When Omicron started flying all over the country, people said everything was okay, it was a way to improve people’s immunity,” her college, Imperial College London, Rosemary Boyton, study. It begins with a statement from the co-authors of, Conclusion: “What we are saying is that it is not a good immune booster.”

For those who received triple vaccination and had not previously had a Covid infection, Omicron provided a more pronounced immune boost to the previous mutant and a much smaller boost to Omicron itself. Those who were infected during the first wave of the pandemic and then re-infected with Omicron did not have any kind of enhancement. “If you get infected during the first wave, you can’t boost your immune response with an Omicron infection,” says Boyton.

Still, vaccines cannot prevent reinfection, but the research team warned that vaccination is still essential to protect against the more serious consequences of being infected with Covid.

The study was based on a sample from 731 UK healthcare professionals followed up between March 2020 and January 2022. At the third dose, we sought to investigate the response of the antibody to the Omicron mutant submutant BA.1 and the two cell types known as T cells and B cells.

The results obtained showed that in the weeks following the third dose, the levels of T cells against Omicron protein decreased and the levels of antibodies against Omicron protein decreased, regardless of whether the participants were already infected with Covid. I suggested that I did. Against other variants.

However, the history of infection proved to be important in some of the other discoveries made during the study. According to the research team, infection with the Omicron variant enhances protection against future infections with other variants, but does not improve protection against reinfection with Omicron. When they were infected with the first wave of the virus and then with Omicron, their immunity was further weakened.

“Immune imprint”

This finding has overridden the idea that infection with any of the mutants is a way to boost an individual’s immune response. On the contrary, what appears to be outbreak is that the protection of a particular individual against future infections of any variant depends on the history of infection and its vaccination. This is a reaction known as “imprinting”.

According to researchers, this diversity in the history of infection and vaccination felt by study participants is important for “immunization” not only to better understand the virus, but also to better understand the related issues. Future new variants or herd immunity that were essential to be able to understand sex.

Findings show that people who have never been infected with Covid-19 and who were infected with Omicron only after three vaccinations were tested against B cells and T cells in laboratory tests against previous variants such as alpha and delta. It shows that the immunity was good. Against Omicron. People infected with alpha in the early stages of the pandemic had less antibody response to Omicron.

What appears to be highly emphasized in this study is the reduction in the effects of Omicron on an individual’s immunity. “Omicron, as we thought, turned out to be far from the natural booster of benign vaccine immunity, but is a particularly stealth antigenic escaper,” said study co-author Danny Altman. Explains in the statement.

According to Altman, new discoveries may be important, especially in the development of new vaccines that may be needed, especially now that the myth of herd immunity has been uncovered. “We have not acquired herd immunity. We have not built defensive immunity for Omicron,” he emphasized.

Still, in many parts of the world, the new wave of Covid seems to be less and less likely to cause hospitalization and other serious consequences. This suggests that despite the history of people’s infection or vaccination, there is immunity that appears to be built against the most serious forms of Covid. However, it is still important to remember the fact that Omicron’s antigenicity and new subvariants are evolving, the study authors point out.

“One concern is that Omicron can mutate,” Boyton explains. “In this scenario, people with Omicron infections will not be fully enhanced against future infections, depending on their” imprinting “,” he adds.

Leave a Comment

Your email address will not be published.