Obesity, Cancer, Obesity Surgery-Andr Murad

Among obese adults, those who intentionally lost weight with obesity surgery had significantly lower obesity-related cancer and cancer-related mortality than those without surgery, researchers say. Reported in a recently published clinical study in the magazine JAMA.

Obesity surgery is currently the most effective treatment available for obesity. Patients usually lose 20% to 35% of their body weight after surgery, which usually lasts for years. In parallel, several observational studies have reported an association between obesity surgery and reduced cancer risk. Therefore, a prospective pair cohort study SPLENDID was conducted.

The study enrolled 30,318 adults (mean age 46 years, 77% female), of whom 5,053 had a BMI (body mass index) of 35 kg / m2 or higher and were in the United States between 2004 and 2017. I had an obesity surgery under my medical system. These patients were consistent with 25,265 obese patients who did not undergo obesity surgery. The primary endpoint was time to cancer development associated with obesity and cancer-related mortality.

After an average follow-up of 6.1 years, the average weight difference between the 10-year groups was 24.8 kg, and the weight loss of patients who underwent obesity surgery increased by 19.2%. During follow-up, 96 patients and 780 non-surgical patients who underwent obesity surgery developed obesity-related cancer events (3 vs. 4.6 events per 1000 person-years). The cumulative incidence of obesity-related cancers after 10 years was 2.9% in patients who underwent obesity surgery and 4.9% in non-surgery patients.

Overall, 21 surgical and 205 non-surgical patients showed cancer-related mortality (0.6 vs. 1.2 events per 1,000 person-years). The cumulative incidence of cancer-related mortality after 10 years was 0.8% in the surgical group and 1.4% in the non-surgery patients.

This study shows an important link between weight loss surgery and reduced cancer incidence and cancer-related mortality, but it is the most basic question to clarify these auspicious data. More research is needed to deal with it, especially by including a large number of patients. patient. Includes, well-designed, cancer screening data, tumor registration data, more detailed individual patient data, and the basic mechanism of efficacy, in this case a weight loss study.

If this association is effectively identified, the indications for obesity surgery extend its benefits to another equally important health area, cancer prevention.

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