January Omicron infection does not protect from current version | Health

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Cases of Covid-19 surged 326% in Brazilian pharmacies in May.

Antibodies produced by infection with the original version of Ômicron (BA.1) that caused the January Covid-19 wave are not protected from the Brazilian subvariants BA.4 and BA.5. Hmm. The conclusion is a study by researchers at Beijing University in Beijing, China, published this Friday in the scientific journal Nature.

According to an analysis of the Instituto Todospela Saúde (ITpS), which was created using data from the Dasa and DB Molecular Institutes, the proportion of possible cases of BA.4 and BA.5 in the country increased from 10.4% to 44%. .. The other samples are from the BA.2 subline. At the same time, the positive rate for Covid-19 (the percentage of tests with positive results) increased from 23.6% to 42.3%.

“Short-term increases indicate that these variants are more contagious because they can overcome the subspecies that were prevalent at the time, in this case Omicron BA. 2. BA.4 and BA. Five variants are derived from BA.2 and this is the first time this has occurred in a pandemic. VOCs (variants of concern) derived from their predecessor VOCs have created a new wave. It didn’t happen before. The previous wave was caused by a VOC that didn’t come from the previous one, “said José Eduardo Levi, a bachelor of arts at Dasa.

However, ITpS warned that due to the range of vaccination, the effects of the current version of the disease tend to be lower than in the January wave. This is because protection from the most serious forms of Covid is still expected. -19.19.

In May, a study by South African scientists, the first place to identify new substrains, had already examined the ability to avoid antibodies from previous Covid-19 infections, but in vaccinated people. The ability to reproduce in the blood is low.

In addition to the ability of new subvariants to evade immunity, another reason for the high reinfection rate is the response produced by BA.1. Omicron infections have resulted in immunopotentiation against early variants (alpha, beta, gamma, delta, and original ancestors), according to a study published in Science by researchers at Imperial College in London, England. , It had little effect on Omicron itself.

Reinfection with BA.4 and BA.5

In a new Chinese study, researchers were generated by BA.1 with or without vaccination to combat BA.4, BA.5, and BA.2.12.1 (the latter predominant in the United States). The response of the antibody was analyzed. They found that mutations present in new subvariants could escape protection and thus cause new infections.

“In contrast to when” Micron “first appeared, the” Micron “subline can target humoral immunity induced by” Micron “itself, such as post-vaccination infections. (…) These phenomena represent the major challenges of herd immunity currently established by vaccination and infection with BA.1 and BA.2. Similarly, they also suggest that an Omicron BA.1-based vaccine (currently under development by Pfizer and Moderna) may not be the ideal antigen for inducing broad-spectrum protection against new Omicron sublines. “It’s done,” wrote a Chinese researcher.

This month, Moderna, the pharmaceutical company responsible for one of the world’s vaccines against Covid-19, said that a specific version of the immune drug under development for Ômicron is eight times more resistant to mutants than the booster of the current formulation. Announced that it induced many antibodies. The institute’s CEO, Stephane Bancel, said he expects new applications to be available in September. However, the new vaccine is based on BA.1 and Chinese scientists believe it may limit defense against new sub-strains.

Most symptomatic infections

In addition, preliminary data from a study conducted by scientists at the University of Tokyo that has not yet been peer-reviewed regained the ability of subvariants BA.4, BA.5, and BA.2.12.1 to infect cells. Indicates that there is a possibility. Of the lungs, make them more pathogenic and resemble early Covid-19 variants such as Delta.

Scientists believe that BA.1 and BA.2 – early subvariants of micron – cause a milder condition by infecting the upper respiratory tract rather than the lungs. The results of a Japanese study show that BA.4 and BA.5 no longer take this action and can cause more serious symptoms.

However, experts point out that vaccination can still prevent death from the most serious cases and illnesses. Therefore, they can escape previous immunity and cause more serious infections, but the new subline is as great as the previous Covid-19 wave, affecting the health system or immunized people. I don’t think it should pose a threat.

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