How Exercise Lose Weight: Discovering Molecules Participating in This Process-Science

Exercise is good. It helps control weight and can extend lifespan. Unfortunately, we don’t know how muscle activity produces these benefits.Now scientists are beginning to understand its molecular mechanism Turn muscle activity into longevity.. Molecules involved in this process have been discovered.

Scientists compared the blood of mice and horses after intense training with the blood of the same animal just before training. We know that there are many components whose blood levels change after exercise, but a new mass spectrometer (a type of device) can be used to identify molecules that are present in small amounts, such as new hormones.

In both horses, humans and mice, scientists have discovered new molecules that increase in concentration after exercise. It is a dimer: a lactic acid molecule bound to a phenylalanine (Lac-Phe) molecule. Lactic acid is produced by muscles when we exercise. Phenylalanine is one of the 20 amino acids that make up our protein.

By analyzing how Lac-Phe is produced, scientists have discovered an enzyme that binds lactic acid to phenylalanine. And based on that information, they produced large amounts of Lac-Phe and genetically modified mice without enzymes.

In the first experiment, they injected Lac-Phe into non-exercising mice. They observed that these mice had the same reduced appetite as exercised mice. When the substance was injected for days in a row, the mice lost weight and adipose tissue, similar to exercised mice.

This experiment Lac-Phe causes appetite and weight loss even in the absence of muscle activity. Scientists then exercised mice that were unable to produce Lac-Phe. These animals did not lose weight or appetite, despite a lot of exercise. However, when these same animals were given Luckfe injections, they lost their appetite and weight again. These experiments show that Lac-Phe is one of the molecules that control post-exercise appetite and weight loss.

New drugs based on this discovery may help you to benefit from exercise without activity.

More information: Exercise-induced metabolites that suppress feeding and obesity. Nature.

* Biologist, Ph.D. in Cellular and Molecular Biology from Cornell University, author of the arrival of the new coronavirus in Brazil.Lotus reef, mosquito slide; and cannibalistic cricket long march

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